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Interactions between U(VI) and bovine serum albumin

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成果类型:
期刊论文
作者:
Yang, Yan;Feng, Yixiao;Wang, Yanfei*;Wang, Lin;Shi, Weiqun
通讯作者:
Wang, Yanfei
作者机构:
[Yang, Yan; Wang, Yanfei] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
[Feng, Yixiao; Shi, Weiqun; Wang, Lin] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China.
通讯机构:
[Wang, Yanfei] U
Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Uranium;BSA;Secondary structure;FT-IR/ATR
期刊:
Journal of Radioanalytical and Nuclear Chemistry
ISSN:
0236-5731
年:
2013
卷:
298
期:
2
页码:
903-908
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11275219, 21201166]; Major Research Plan "Breeding and Trans-mutation of Nuclear Fuel in Advanced Nuclear Fission Energy System" of the Natural Science Foundation of China [91026007]
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
摘要:
Interest in bio-toxicology of uranium resulting from its radioactive heavy metal property has been growing enormously in recent years. The interactions between uranium(VI) [U(VI)] and bovine serum albumin (BSA) at physiological pH were studied by spectroscopic methods. Fuorescence results revealed the formation of BSA–U(VI) complex, the binding constants as well as the number of binding sites were determined. In particular, the effects of U(VI) binding on the secondary structures of BSA were examined by means of Fourier transformation infrared...

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