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EndMT-derived mesenchymal stem cells: a new therapeutic target to atherosclerosis treatment

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成果类型:
期刊论文
作者:
Zhang, Xiaofan;Ren, Zhong;Jiang, Zhisheng
通讯作者:
Zhisheng Jiang
作者机构:
[Ren, Zhong; Jiang, Zhisheng; Zhang, Xiaofan] Univ South China, Hengyang Med Sch, Int Joint Lab Arteriosclerot Dis Res Hunan Prov, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang 421001, Peoples R China.
通讯机构:
[Zhisheng Jiang] I
Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Hengyang Medical School, University of South China, Hengyang, China
语种:
英文
关键词:
Mesenchymal stem cell (MSC);Atherosclerosis;Endothelial-to-mesenchymal transition (EndMT);Haemangioblast;Blood cell
期刊:
Molecular and Cellular Biochemistry
ISSN:
0300-8177
年:
2023
卷:
478
期:
4
页码:
755-765
基金类别:
This article was supported by Project of Health Commission of Hunan Province (Grant No. 202102061771 to Z Ren), National Natural Science Foundation of China (Grant No. 91839103 to Z Jiang), National Key Research and Development Program of China (Grant No. 2019YFA0801601 to Z Jiang), “Double First-Class” project for innovative Group of Basic Medicine of Hunan Province, and College Students Innovation and Entrepreneurship Training Program of University of South China (Grant No. X2019146 to X Zhang).
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Cardiovascular diseases, such as coronary artery disease and stroke, are the main threats to human health worldwide. Atherosclerosis, a chronic inflammatory disorder, plays a role as an initiator of all of the above-mentioned diseases. Cell therapy for diseases has attracted widespread attention. Mesenchymal stem cells (MSCs) are a type of stem cell that still exist in adults and have the characteristics of self-renewal ability, pluripotent differentiation potential, immunomodulation, tissue regeneration, anti-inflammation and low immunogenicity. In light of the properties of MSCs, some resear...

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