期刊论文

Zhou, Q;Min, Junxia;Wang, FD

英文

细胞研究

1001-0602

2022

32

7

687-690

10.1038/s41422-022-00642-w

We thank the Cryo-EM Facility, the High-Performance Computing Center, and the Mass Spectrometry & Metabolomics Core Facility at Westlake University, the core facilities at Zhejiang University School of Medicine, and the Radioisotope Laboratory of Center of Biomedical Analysis at Tsinghua University for technical support. We thank Dr. Jiaming Wang, Ms. Yao He, Ms. Jie Shen, and Mr. Junyi Chen in the Wang and Min laboratories for technical assistance. We also thank Dr. Sufen Zhang and Dr. Zhiyang Yu at the College of Agriculture and Biotechnology, Institute of Nuclear-Agricultural Science, Zhejiang University, for assistance with the [C]-cystine uptake assay. We apologize to any of our colleagues whose valuable contributions were not cited in this manuscript due entirely to space limitations. This study was supported by research grants from the National Key R&D Program of China (2018YFA0507801 to J.M.; 2018YFA0507802 to F.W.; and 2020YFA0509300 to Q.Z.) and the National Natural Science Foundation of China (31930057 to F.W.; 31970689 to J.M.; and 31971123 to Q.Z.). 14

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Dear Editor, Ferroptosis is an iron-dependent,non-apoptotic form of regulated cell death characterized by an accumulation of lipid-derived reactive oxygen species(ROS).The small-molecule compound erastin induces ferroptosis via inhibiting the cystine-glutamate antiporter system xc-,which consists of two subunits,namely the light chain xCT and the heavy chain 4F2hc(encoded by the SLC7A11 and SLC3A2 genes,respectively).1-4 Recent studies have shown that xCT(SLC7A11)regulates ferroptosis in liver fibrosis,cardiomyopathy,and numerous other pathoph...