The SARS-CoV-2 rS1-E-PLGA nanovaccine and evaluation of its immune effect in BALB/c mice

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成果类型：

期刊论文

作者：

Huang, J.;Ding, Y.;Yao, J.;Peng, K.;Deng, K.;...

通讯作者：

Zuo, J.

作者机构：

[Zuo, J.; Deng, K.; Zhang, M.; Huang, J.; Zhang, Y.] Univ South China, Lab Translat Med, Hengyang, Hunan, Peoples R China.

[Zuo, J.; Ding, Y.; Yao, J.] Univ South China, Nanhua Hosp, Hengyang, Hunan, Peoples R China.

[Zuo, J.] Univ South China, Affiliated Hosp 3, Hengyang, Hunan, Peoples R China.

[Peng, K.] Univ South China, Inst Pathogen Biol, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

通讯机构：

[Zuo, J.] T

The Laboratory of Translational Medicine, Hunan, China

语种：

英文

关键词：

COVID-19;Enevolpe protein;Nanovaccine;PLGA;Spike protein

期刊：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES

ISSN：

1128-3602

年：

2022

卷：

期：

页码：

5255-5263

DOI：

10.26355/eurrev_202207_29316

基金类别：

This work is supported by the Key Research Program from the Science and Technology Department of Ningxia Hui Autonomous Region, China (2019BFH02012); the Key Research Program of Hunan Health Committee (20201909); the Program of Hengyang Science and Technology Bureau (2020-67).

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

OBJECTIVE: Vaccination is an important method for preventing COVID-19 infection. However, certain vaccines do not meet the current needs. To improve the vaccine effect, discard ineffective antigens, and focus on high-quality antigenic clusters, S1-E bivalent antigens were designed. MATERIALS AND METHODS: Vaccine delivery is performed using poly (lactic-co-glycolic acid) (PLGA). Here, the recombinant S1-E (rS1-E) was covered on PLGA and injected intra-muscularly into mice. In total, 48 BALB/c mice were randomly divided into six groups with 8 mic...

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The SARS-CoV-2 rS1-E-PLGA nanovaccine and evaluation of its immune effect in BALB/c mice

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