Molecular imprinting technology (MIT) with predetermination, specific recognition and practicability is widely used in the domain of biosensor, membrane and isomer separation, antibody mimics, enzyme-mimic catalyst and solid phase extraction (SPE).SPE is a better,more simple and more convenient separation technology than liquid-liquid extraction,and has developed rapidly in recent three decades.It is a hopeful domain that uses molecularly imprinted polymers as solid phase extraction packing (MISPE).In this paper, a brief introduction is given about the origin, principle and methods of molecula...