Apelin-13 enhances contextual fear extinction in rats

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成果类型：

期刊论文

作者：

Chen, Fang-Ling;Li, Jie;Wang, Bo;Tian, Shao-Wen*;Long, Chen*

通讯作者：

Tian, Shao-Wen;Long, Chen

作者机构：

[Li, Jie; Tian, Shao-Wen; Chen, Fang-Ling] Univ South China, Dept Physiol, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Wang, Bo] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Tian, Shao-Wen] Guilin Med Univ, Guangxi Key Lab Brain & Cognit Neurosci, Guilin 541000, Guangxi, Peoples R China.

[Long, Chen] Cent S Univ, Xiangya Hosp 2, Dept Minimally Invas Surg, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Tian, Shao-Wen] U

[Long, Chen] C

Univ South China, Dept Physiol, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.

Cent S Univ, Xiangya Hosp 2, Dept Minimally Invas Surg, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Apelin-13;Fear extinction;Memory;PTSD;Rats

期刊：

Neuroscience Letters

ISSN：

0304-3940

年：

2019

卷：

712

页码：

134487

DOI：

10.1016/j.neulet.2019.134487

基金类别：

Guangxi Key Laboratory of Brain and Cognitive Neuroscience [GKLBCN-20190102]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81771170]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ40237, 2019JJ50548, 2019JJ50551, 2018JJ3465, 2018JJ2359]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Fear extinction is considered as a new learning process that is valid to model features of post-traumatic stress disorder (PTSD). The neuropeptide apelin, such as apelin-13, apelin-17 and apelin-36, are endogenous ligands of the G-protein coupled receptor APJ. Apelin and its receptor APJ are widely distributed in the central nervous system. Accumulating evidence suggests the critical role of apelin-13 in modulation of learning and memory, however, its specific role in fear extinction remains unclear. In the present study, we investigated the effect of apelin-13 administration on contextual fea...

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Apelin-13 enhances contextual fear extinction in rats

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