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Apelin-13 enhances contextual fear extinction in rats

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成果类型:
期刊论文
作者:
Chen, Fang-Ling;Li, Jie;Wang, Bo;Tian, Shao-Wen*;Long, Chen*
通讯作者:
Tian, Shao-Wen;Long, Chen
作者机构:
[Li, Jie; Tian, Shao-Wen; Chen, Fang-Ling] Univ South China, Dept Physiol, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.
[Wang, Bo] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.
[Tian, Shao-Wen] Guilin Med Univ, Guangxi Key Lab Brain & Cognit Neurosci, Guilin 541000, Guangxi, Peoples R China.
[Long, Chen] Cent S Univ, Xiangya Hosp 2, Dept Minimally Invas Surg, Changsha 410011, Hunan, Peoples R China.
通讯机构:
[Tian, Shao-Wen] U
[Long, Chen] C
Univ South China, Dept Physiol, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.
Cent S Univ, Xiangya Hosp 2, Dept Minimally Invas Surg, Changsha 410011, Hunan, Peoples R China.
语种:
英文
关键词:
apelin;apelin 13;apelin receptor;ligand;unclassified drug;apelin-13 peptide;signal peptide;animal experiment;anxiety;Article;controlled study;fear;freezing;learning;locomotion;male;memory;neuromodulation;nonhuman;posttraumatic stress disorder;priority journal;rat;recall;animal;associative learning;conditioned reflex;drug effect;fear;physiology;reinforcement;Sprague Dawley rat;Animals;Association Learning;Conditioning, Classical;Extinction, Psychological;Fear;Intercellular Signaling Peptides and Proteins;Locomotion;Male;Mental Recall;Rats;Rats, Sprague-Dawley
期刊:
Neuroscience Letters
ISSN:
0304-3940
年:
2019
卷:
712
页码:
134487
基金类别:
The project was supported by Guangxi Key Laboratory of Brain and Cognitive Neuroscience (GKLBCN-20190102), National Natural Science Foundation of China (81771170) and the Hunan Provincial Natural Science Foundation of China (2019JJ40237; 2019JJ50548; 2019JJ50551; 2018JJ3465; 2018JJ2359).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Fear extinction is considered as a new learning process that is valid to model features of post-traumatic stress disorder (PTSD). The neuropeptide apelin, such as apelin-13, apelin-17 and apelin-36, are endogenous ligands of the G-protein coupled receptor APJ. Apelin and its receptor APJ are widely distributed in the central nervous system. Accumulating evidence suggests the critical role of apelin-13 in modulation of learning and memory, however, its specific role in fear extinction remains unclear. In the present study, we investigated the ef...

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