Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: Potential role in atherosclerosis

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成果类型：

期刊论文

作者：

Wei, Dang-Heng*;Jia, Xiao-Ying;Liu, Yang-Hui;Guo, Feng-Xia;Tang, Zhi-Han;...

通讯作者：

Wei, Dang-Heng

作者机构：

[Jia, Xiao-Ying; Tang, Zhi-Han; Jian, Zhi-Sheng; Wei, Dang-Heng; Li, Xiao-Hong; Liu, Yang-Hui; Guo, Feng-Xia; Wang, Zuo; Liu, Lu-Shan] Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Peoples R China.

[Jia, Xiao-Ying] Xiangnan Univ, Dept Nursing, Chenzhou 423000, Peoples R China.

[Wang, Gui-Xue; Wei, Dang-Heng] Chongqing Univ, Bioengn Coll, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China.

[Wei, Dang-Heng; Ruan, Chang-Geng] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Key Lab Thrombosis & Hemostasis,Minist Hlth, Suzhou 215006, Peoples R China.

[Wei, Dang-Heng] Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 42001, Peoples R China.

通讯机构：

[Wei, Dang-Heng] U

Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 42001, Peoples R China.

语种：

英文

关键词：

Apoptosis;Autophagy;Cathepsin L;Endothelial cell;Oxidized low-density lipoprotein;Permeability

期刊：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ISSN：

1107-3756

年：

2013

卷：

期：

页码：

400-406

DOI：

10.3892/ijmm.2012.1201

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30800449]; Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province; Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), the Ministry of Education

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The activation of endothelial cells by oxidized low-density lipoprotein (ox-LDL) with subsequent increases in endothelial permeability occurs in the early stage of atherosclerosis. Cathepsin L (CATL) is one of the cysteine proteases and has been implicated in advanced atherosclerotic lesions and plaque instability. This study aimed to explore the role of CATL in ox-LDL-induced early atherosclerotic events and to delineate the underlying mechanism. Results showed that ox-LDL upregulated CATL protein levels and activation in human umbilical vein endothelial cells (ECs) in a concentration-depende...

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Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: Potential role in atherosclerosis

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