期刊论文

Research progress of estrogen-related receptor α in cancer

中文

临床与病理杂志

2095-6959

2019

39

8

1799-1804

10.3978/j.issn.2095-6959.2019.08.028

2017A030313668:广东省自然科学基金 JCYJ20160328161613864:深圳市科技创新项目 JSGG20170414104216477:深圳市科技创新项目

本校为第一机构

孤儿核受体雌激素相关受体α（estrogen-related receptorα,ERRα）是核受体超家族（nuclear receptor superfamily,NR s）中无需和配体结合便可发挥其生物学功能的特殊类型。早期对ERRα的研究主要侧重于其参与和影响雌激素信号转导途径,以及其对机体正常能量代谢的调控研究。近年来,研究发现ERRα能在肿瘤发生和发展进程中调控肿瘤细胞的代谢重编程来满足其能量需求。ERRα在肿瘤领域受到广泛的关注还表现在其用于靶向治疗的成药潜力,以及对肿瘤患者不良预后的评估作用等方面。

Orphan nuclear receptor ERRα(estrogen-related receptor α,ERRα) is a special type of the nuclear receptor superfamily that can exert the biological function without binding to the ligand.Early studies on ERRα are aimed at its effects on estrogen signaling pathways and regulation of normal energy metabolism in vivo.In recent years,ERRα is found to regulate the metabolic reprogramming of tumor cells in the process of tumorigenesis and development to meet its energy requirements.The orphan nuclear receptor ERRα has received extensive attentio...