期刊论文

Hu, Xiao-Bo

英文

中华医学杂志(英文版)

0366-6999

2020

133

1

68-73

10.1097/CM9.0000000000000583

This work was supported by grants from the National Natural Science Foundation of China (No. 41877390), the Nature Science Fund of Hunan Province (Nos. 2016JJ2113, 2018JJ3458, 2019JJ40241), the Science Fund of Hunan Provincial Education Department (No. 16A186), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (No. 0223-0002-0002000-54), and the Graduate Education and Innovation Fund of University of South China (No. 2017JG022).

本校为第一且通讯机构

OBJECTIVE: Type 1 diabetes (T1D) results from dysfunction of pancreatic islets beta cells. Recent studies supported that endoplasmic reticulum (ER) stress takes an important role in pancreatic beta cell excessive loss, resulting in T1D. Here, we aimed to review the relationship between ER stress and T1D. Additionally, we also reviewed the potential mechanisms underlying ER stress mediated T1D. DATA SOURCES: This review was based on the articles from PubMed databases up to July 2019, with the following keywords: "endoplasmic reticulum stress", "inflammation", "autoimmunity", and "type 1 diabete...