期刊论文

Correlation of apoA-Ⅰ and ABCA1 in Reverse Cholesterol Transport

中文

医学分子生物学杂志

1672-8009

2005

2

5

385-388

10.3870/j.issn.1672-8009.2005.05.015

国家自然科学基金（No．30470720）~~；

本校为第一机构

载脂蛋白A-Ⅰ(apolipoprotein,apoA-Ⅰ)是高密度脂蛋白(high density lipoprotein,HDL)所含主要的载脂蛋白成分,ATP结合盒转运体A1(ATP binding casstte transporter A1,ABCA1)是细胞膜脂类主动转运体.apoA-Ⅰ与ABCA1结合而被脂化是胆固醇逆转运(reverse cholesterol transport,RCT)的关键步骤,是HDL抗动脉粥样硬化(atherosclerosis,AS)性心血管疾病的主要机制之一.研究和认识apoA-Ⅰ与ABCA1的分子结构、功能以及二者在RCT中的相关性,对于揭示抗AS的机理具有重要意义.

Apolipoprotein （apo） A-Ⅰ is the major apoliprotein component of high density lipoprotein （HDL）, and ATP binding cassette transporter A1（ABCA1） is a cell - membrane transporter which actively transports cholesterol and phospholipids. ApoA-Ⅰ binding to the extracellular domain of ABCA1 results in the activation of apoA-Ⅰ lipidation, which is a key step in reverse cholesterol transport （RCT） process,and one ot the major mechanisms by which HDL works against atherosclerotic cadiovascular diseases.Understanding of their molecular structur...