Nanhua Univ, Inst Pathogen Biol, Hengyang 421001, Peoples R China.
语种：
英文
关键词：
HDAXX;E1B55-kDa;PML;hDaxx · adenovirus type 12 · transcriptional repression · oncoprotein
关键词(中文)：
转录抑制;致癌作用;腺病毒型12;早幼粒细胞白血病
期刊：
中华医学杂志(英文版)
ISSN：
0366-6999
年：
2004
卷：
117
期：
5
页码：
753-757
基金类别：
the Education Committee of Hunan Province Fundation
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Background. Daxx has been identified as a nuclear protein that involves in apoptosis and transcriptional repression. Daxx co-localizes with the promyelocytic leukemia (PML) protein and regulates transcription. Human Daxx (hDaxx) is a protein that functions as a transcriptional regulation through its interaction with some DNA-associated proteins. The aim of this study was to explore the transcriptional regulatory effect of hDaxx interacting with adenovirus (Ad) 12 E1B (Ad12E1B) 55-kDa oncoprotein. Methods. The co-localization of hDaxx-Ad12E1B or hDaxx-PML protein in the nucleus was observed und...
