期刊论文

Chen, J.X.

中文

中华医学杂志

0376-2491

1994

74

1

38-39

本校为第一机构

观察了以内毒素作为致病原在支气管高反应性形成中的作用。结果：豚鼠腹腔注射内毒素后，其气道对组织胺引起哮喘潜伏期明显缩短，组织胺收缩离体气管平滑肌的ＰＤ２值明显增高，异丙肾上腺素松弛作用的ＰＤ２值显著降低，同时血浆及肺及肺组织中组织胺含量显著增高。提示内素可能是道感染发支气管高以应性形成的重要因素，其机制与β受体功能改变及组织胺含量升高有关。

Endotoxin was as a pathogen to investigate its effects on bronchial hyperreactivity formation. The latent periods of guinea pigs inhaled histamine and PD2 value of isoproterenol were markedly decreased 4 days after the intraperitoneal injection of endotoxin 1 mg/kg, meanwhile PD2 value of histamine and histamine levels of lung tissue and plasma were increased significantly. These results indicate that endotoxin is a very important factor in...