Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Renbo;Deng, Xiangping;Peng, Yijiao;Feng, Wanshi;Xiong, Runde;...

通讯作者：

Tang, Guotao

作者机构：

[Deng, Xiangping; Xie, Zhizhong; Liu, Renbo; Lei, Xiaoyong; Peng, Yijiao; Zou, Yang; Tang, Guotao; Feng, Wanshi; Xiong, Runde; Zheng, Xing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang City, Peoples R China.

[Deng, Xiangping; Liu, Renbo; Tang, Guotao] Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang City, Hunan, Peoples R China.

[Tang, Guotao] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Guotao] U

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Anti-tumor;Flavonoid;Glycolysis;HIF-1alpha;Microtubules

期刊：

Bioorganic Chemistry

ISSN：

0045-2068

年：

2020

卷：

页码：

103652

DOI：

10.1016/j.bioorg.2020.103652

基金类别：

This work was financially supported by Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research (Approval number: 2019-56) and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study.

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

5,6,7-Trimethoxy flavonoid salicylate derivatives were designed by the joining of three important pharmacophores (TMP, flavonoid, and SA) according to the combination principle. A series of novel trimethoxy flavonoid salicylate derivatives were synthesized and their in vitro anti-tumor activities were evaluated. Among these derivatives, compound 7f exhibited excellent antiproliferative activity against HGC-27 cells and MGC-803 cells with IC50 values of 10.26 ± 6.94 μM and 17.17 ± 3.03 μM, respectively. Subsequently, the effects on cell colo...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问