Synthesis and Biological Evaluation of Novel Genistein Amino Acid Ester Derivatives as Potential Anti-Tumor Agents

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成果类型：

期刊论文

作者：

Long, Xiao-kang;Liao, Lan-Qing;Zeng, Yao-Fu;Zhang, Ye;Xiao, Fang;...

通讯作者：

Guo, Yu;Li, Chong

作者机构：

[Liao, Lan-Qing; Guo, Yu; Zhang, Ye; Zeng, Yao-Fu; Long, Xiao-kang; Xiao, Fang] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

[Li, Chong] Univ South China, Nanhua Affiliated Hosp, Hengyang, Peoples R China.

通讯机构：

[Guo, Yu; Li, Chong] U

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

Univ South China, Nanhua Affiliated Hosp, Hengyang, Peoples R China.

语种：

英文

关键词：

amino acid;anti-tumor;genistein

期刊：

ChemistrySelect

ISSN：

2365-6549

年：

2019

卷：

期：

页码：

5662-5666

DOI：

10.1002/slct.201900857

基金类别：

This work was supported by the Construct Program of the Key Discipline in Hunan Province(17 A190), and Hengyang City, Hunan Province Joint Fund Project of China(2018JJ4036).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

AbstractThirty‐one novel genistein amino acid ester derivatives were synthesized and evaluated for their anti‐proliferative activities against HUVEC cells and five cancer cells lines (HCT‐116, HeLa, HepG‐2, MCF‐7, MGC‐803). Most of the amino acid ester derivatives exhibited more inhibitory activity than their parent compound genistein. In particular, compound 8 j (methyl(4‐((5‐hydroxy‐3‐(4‐hydroxyphenyl)‐4‐oxo‐4H‐chromen‐7‐yl)oxy)butanoyl)tryptophanate) bearing tryptophan chain showed the most cytotoxicity against HCT‐116 cel...

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Synthesis and Biological Evaluation of Novel Genistein Amino Acid Ester Derivatives as Potential Anti-Tumor Agents

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