Hunan Natural Science Foundation Project [2018JJ2349]; University of South China Students Research Learning and Innovative Experimental Project [2018147200]; Graduate student science foundation of University of South China [2018496]
机构署名：
本校为第一且通讯机构
院系归属：
化学化工学院
药学与生物科学学院
摘要：
A series of chrysin amino acid derivatives were synthesized to evaluate for their antiproliferative activities against several cancer cell lines. Among the compounds tested, N-(2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)octanoyl)-L-leucine methyl ester(5d) presented a good anti-proliferative activity in MDA-MB-231 and MCF-7 cells. Flow cytometry analysis showed that 5d induced apoptosis and prolonged cell cycle progression in MDA-MB-231 and MCF-7 cells. Western blot analysis showed that 5d significantly inhibited Akt phosphorylation (Ser473) in MDA-MB-231 and MCF-7 cells. In addition, 5d...
