Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation

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成果类型：

期刊论文

作者：

Li, Jing;Li, Liang;Guo, DongMing;Li, SuYun;Zeng, YuXin;...

通讯作者：

Xie, Wei

作者机构：

[Guo, DongMing; Liu, ChuHao; Xie, Wei; Li, Jing; Li, SuYun; Fu, Ru] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China.

[Liu, ChuHao; Li, Jing; Fu, Ru] Univ South China, Clin Med, Hengyang 421001, Hunan, Peoples R China.

[Li, Liang] Univ South China, Dept Pathophysiol, Hengyang 421001, Hunan, Peoples R China.

[Zeng, YuXin] Univ South China, Hengyang 421001, Hunan, Peoples R China.

[Huang, MengQian] Capital Med Univ, Fuxing Hosp, Clin Med, Beijing 100038, Peoples R China.

通讯机构：

[Xie, Wei] U

Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Angiopoietin-like proteins;Dyslipidemia;Fatty acid metabolism;Lipid metabolism;Lipoprotein lipase;Triglycerides

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2020

卷：

503

页码：

19-34

DOI：

10.1016/j.cca.2019.12.029

基金类别：

The authors gratefully acknowledge the financial supports from the National Natural Sciences Foundation of China ( 81800386 ), the Hunan Provincial Natural Science Foundation of China ( 2017JJ2234 , 2018JJ3453 ), the start-up funds for Ph.Ds in University of South China ( 2017XQD12 , 2017XQD05 ), Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City ( 2017KJ182 ) and College Students’ Research Learning and Innovative Experiment Plan in University of South China ( 2018XJXZ383 , 2017XJXZ033 ), the National Students’ Research Learning and Innovative Experiment Plan ( 201810555017 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Hypertriglyceridemia is a risk factor for a series of diseases, such as cardiovascular disease (CVD), diabetes and nonalcoholic fatty liver disease (NAFLD). Angiopoietin-like proteins (ANGPTLs) family, especially ANGPTL3, ANGPTL4 and ANGPTL8, which regulate lipoprotein lipase (LPL) activity, play pivotal roles in triglyceride (TG) metabolism and related diseases/complications. There are many transcriptional and post-transcriptional factors that participate in physiological and pathological regulation of ANGPTLs to affect triglyceride metabolism. This review is intended to focus on the similari...

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Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation

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