期刊论文

Guo, Y

英文

European Journal of Medicinal Chemistry

0223-5234

2024

268

116274

10.1016/j.ejmech.2024.116274

CRediT authorship contribution statement Ruige Yang: Writing – original draft, Data curation, Conceptualization. Wanqing Cheng: Methodology, Investigation. Meijuan Huang: Methodology. Ting Xu: Data curation. Miaomiao Zhang: Investigation. Jifeng Liu: Conceptualization. Shangshang Qin: Supervision, Conceptualization. Yong Guo: Writing – review & editing, Supervision, Project administration, acquisition, Conceptualization.

本校为第一且通讯机构

Methicillin-resistant Staphylococcus aureus (MRSA) is a widespread pathogen causing clinical infections and is multi-resistant to many antibiotics, making it urgent need to develop novel antibacterials to combat MRSA. Here, a series of novel isoxanthohumol-amine conjugates were synthesized as antibacterials. After bioactivity evaluation, a compound E2 was obtained, which showed excellent antibacterial activity against S. aureus and clinical MRSA isolates (MICs=0.25-1μg/mL), superior to vancomycin, and with negligible hemolysis and good membran...