A role for forkhead box A1 in acute lung injury

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成果类型：

期刊论文

作者：

Song, Lan;Zhang, Bin;Feng, Yansheng;Luo, Xinjing;Wei, Xing;...

通讯作者：

Xiao, Xianzhong

作者机构：

[Wei, Xing; Xiao, Xianzhong; Feng, Yansheng; Zhang, Bin; Song, Lan; Luo, Xinjing] Cent S Univ, Lab Shock, Dept Pathophysiol, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China.

[Song, Lan] Nanhua Univ, Coll Life Sci, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Xianzhong] Cent S Univ, Lab Shock, Dept Pathophysiol, Xiangya Sch Med, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Xiao, Xianzhong] C

Cent S Univ, Lab Shock, Dept Pathophysiol, Xiangya Sch Med, 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

acute lung injury;forkhead box A1;apoptosis

期刊：

Inflammation

ISSN：

0360-3997

年：

2009

卷：

期：

页码：

322-332

DOI：

10.1007/s10753-009-9139-x

基金类别：

This work was supported by the National Nature Science Foundation of China (grant no. 30330280), the National Nature Science Foundation of Hunan, China (grant no. 08JJ3030) and the Science Foundation Health Department of Hunan, China (grant no. 2007B090).

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Forkhead box protein A1 (FoxA1) is an evolutionarily conserved winged helix transcription factor with diverse regulatory functions. However, little is known about the role of FoxA1 in acute lung injury (ALI) and pulmonary cell injury. In this study, an in vivo model was employed whereby rats were administered an intravenous injection of oleic acid (OA, 0.1 ml/kg), and alveolar type II epithelial cells (AT-2 cells) injury was induced by hydrogen peroxide (H2O2) in vitro. OA injection resulted in lung injury and AT-2 cells apoptosis in vivo. OA injection and H2O2 upregulated FoxA1 mRNA and prote...

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A role for forkhead box A1 in acute lung injury

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