Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zeng, Ying;Ren, Mei;Li, Yukun;Liu, Yanli;Chen, Cong;...

通讯作者：

Zeng, Xi;Su, Qi

作者机构：

[Li, Yukun; Su, Bo; Su, Qi; Ling, Hui; Su, Jian; Zeng, Ying; Zeng, Xi; Su, Q; Xia, Hong; Liu, Fang] Univ South China, Canc Res Inst, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.

[Ren, Mei; Chen, Cong; Su, Qi; Jiang, Hao; Zeng, Xi; Liu, Yanli] Univ South China, Affiliated Hosp 1, Ctr Gastr Canc Res Hunan Prov, Hengyang, Peoples R China.

[Su, Jian] Univ South China, Affiliated Hosp 2, Dept Pathol, Hengyang, Peoples R China.

[Su, Bo] Univ South China, Inst Pharm & Pharmacol, Key Lab Pharmacoprote, Hunan Prov Univ, Hengyang, Peoples R China.

[Zeng, Ying] Univ South China, Sch Nursing, Hengyang, Peoples R China.

通讯机构：

[Zeng, X; Su, Q] U

Univ South China, Canc Res Inst, Hunan Prov Key Lab Canc Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Chemosensitivity;Gastric cancer;Invasion;Proliferation;RhoGDI2

期刊：

Cancer Letters

ISSN：

0304-3835

年：

2020

卷：

492

页码：

136-146

DOI：

10.1016/j.canlet.2020.07.013

基金类别：

This work is supported by The National Natural Scientific Foundation of China (No. 81973532, No. 81641112 and No. 81374013), the Natural Science Foundation of Hunan Province of China (grant no. 2019JJ50521) and The Patency Foundation of Innovation Platform of Hunan Provincial University of China (No. 17K081). We thank Prof. Qian Tao of the Department of Clinical Oncology, the Chinese University of Hong Kong, for the comments on the manuscript.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

Gastric cancer (GC) is the fifth most common primary malignancy in humans. Rho GDP dissociation inhibitor 2 (RhoGDI2) is overexpressed in multiple cancer types, but the role of RhoGDI2 in GC has not been elucidated. This study aims to determine the level of RhoGDI2 in GC and to confirm the effect of its inhibition or overexpression on GC cell migration, invasion and chemosensitivity. RhoGDI2 level is significantly enhanced in human GC tissue samples in comparison with normal gastric epithelium and corresponding para-cancerous samples. The expression of RhoGDI2 is correlated with clinicopatholo...

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Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway

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