FOXD3 may be a new cellular target biomarker as a hypermethylation gene in human ovarian cancer.

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成果类型：

期刊论文

作者：

Luo, Gui-fang;Chen, Chang-ye;Wang, Juan;Yue, Hai-yan;Tian, Yong;...

通讯作者：

Li, Yu-kun;Li, Yan

作者机构：

[Luo, Gui-fang; Chen, Chang-ye] Univ South China, Affiliated Hosp 1, Dept Gynecol, Hengyang 421001, Peoples R China.

[Wang, Juan] Univ South China, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Yang, Ping; Yue, Hai-yan; Li, Yu-kun] Univ South China, Coll Hunan Prov, Canc Res Inst, Key Lab Tumor Cellular & Mol Pathol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Tian, Yong] Wuhan Univ, Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Enshi Clin Coll, Dept Obstet & Gynecol, Enshi 445000, Hubei, Peoples R China.

[Li, Yan] Cent S Univ, Sch Basic Med Sci, Inst Reprod & Stem Cell Engn, 932 South Lushan Rd, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Li, Yu-kun] U

[Li, Yan] C

Univ South China, Coll Hunan Prov, Canc Res Inst, Key Lab Tumor Cellular & Mol Pathol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Cent S Univ, Sch Basic Med Sci, Inst Reprod & Stem Cell Engn, 932 South Lushan Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Ovarian carcinoma;DNA methylation;5-Aza-dC;FOXD3

期刊：

Cancer Cell International

ISSN：

1475-2867

年：

2019

卷：

期：

页码：

1-13

DOI：

10.1186/s12935-019-0755-8

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: FOXD3 is aberrantly regulated in several tumors, but its underlying mechanisms in ovarian cancer (OC) remains largely unknown. The present study aimed to explore the role and associated mechanisms of FOXD3 in OC. Methods: Microarray data from GEO was used to analyze differential CpG sites and differentially methylated regions (DMR) in tumor tissues and Illumina 450 genome-wide methylation data was employed. The FOXD3 expression level was determined through qRT-PCR and western blot analysis. Wound healing test, colony formation and f...

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FOXD3 may be a new cellular target biomarker as a hypermethylation gene in human ovarian cancer.

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