Macrophage-Activating Lipopeptide-2 Requires Mal and PI3K for Efficient Induction of Heme Oxygenase-1

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成果类型：

期刊论文

作者：

You, Xiaoxing;Liu, Liangzhuan;Zeng, Yanhua;Li, Ranhui;He, Jun;...

通讯作者：

Wu, Yimou

作者机构：

[Jiang, Chuanhao; Wu, Yimou; Liu, Liangzhuan; He, Jun; Ou, Guangli; Zhu, Cuiming; Chen, Liesong; You, Xiaoxing; Yu, Minjun; Zeng, Yanhua; Li, Ranhui; Ma, Xiaohua] Univ South China, Coll Med, Inst Pathogen Biol, Hengyang City, Peoples R China.

[Ma, Xiaohua] Changsha Cent Hosp, Dept Clin Lab, Chagnsha City, Peoples R China.

[He, Jun] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang City, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Coll Med, Inst Pathogen Biol, Hengyang City, Peoples R China.

语种：

英文

关键词：

Transfection;Small interfering RNA;Immune receptor signaling;Inflammation;Phosphorylation;Mycoplasma;Inflammatory diseases;Luciferase

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2014

卷：

期：

页码：

e103433

DOI：

10.1371/journal.pone.0103433

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31000091]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [14JJ2090]; Science and Technology Planning Project of Hunan Province [2013TT2013]; construct program of the key discipline in Hunan Province [2011-75]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

AIMS: This study is to investigate the mechanisms by which macrophage-activating lipopeptide-2 (MALP-2) induces heme oxygenase (HO)-1, a cytoprotective enzyme that catalyzes the degradation of heme, in human monocytes. METHODS: Human monocytic THP-1 cells were cultured for transient transfection with plasmids and stimulation with MALP-2 for indicative time intervals. After incubation with MALP-2, cells were collected and disrupted, before being tested for promoter activity using luciferase assay. For analysis of proteins, immunoreactive bands were detected using an enhanced chemiluminescence W...

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Macrophage-Activating Lipopeptide-2 Requires Mal and PI3K for Efficient Induction of Heme Oxygenase-1

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