Characterization of ferroptosis-triggered pyroptotic signaling in heart failure

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成果类型：

期刊论文

作者：

Bi, Xukun;Wu, Xiaotian;Chen, Jiaqi;Li, Xiaoting;Lin, Yangjun;...

通讯作者：

Fu, GS;Wang, FD;Min, JX

作者机构：

[Fu, GS; Jin, Tingting; Fu, Guosheng; Lin, Yangjun; Bi, Xukun; Li, Xiaoting; Chen, Jiaqi; Wang, Meihui] Zhejiang Univ, Key Lab Cardiovasc Intervent & Regenerat Med Zheji, Sir Run Run Shaw Hosp, Dept Cardiol,Sch Med, Hangzhou, Peoples R China.

[Yu, Yingying; Wang, Fudi; Cheng, Xihao; Wu, Xiaotian; Cai, Zhaoxian] Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, State Key Lab Expt Hematol,Sch Med, Hangzhou, Peoples R China.

[Min, Junxia; Wu, Xiaotian; Min, JX] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Inst Translat Med, Hangzhou, Peoples R China.

[Fang, Xuexian] Hangzhou Normal Univ, Sch Publ Hlth, Dept Nutr & Toxicol, Hangzhou, Peoples R China.

[Han, Shuxian; Han, Peidong] Zhejiang Univ, Affiliated Hosp 4, Ctr Genet Med, Sch Med, Hangzhou, Peoples R China.

通讯机构：

[Wang, FD ; Min, JX ; Fu, GS ] Z

Zhejiang Univ, Key Lab Cardiovasc Intervent & Regenerat Med Zheji, Sir Run Run Shaw Hosp, Dept Cardiol,Sch Med, Hangzhou, Peoples R China.

Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, State Key Lab Expt Hematol,Sch Med, Hangzhou, Peoples R China.

Zhejiang Univ, Sch Med, Affiliated Hosp 1, Inst Translat Med, Hangzhou, Peoples R China.

Univ South China, Sch Publ Hlth, Sch Basic Med Sci, Affiliated Hosp 1,Hengyang Med Sch, Hengyang, Peoples R China.

语种：

英文

期刊：

信号转导与靶向治疗

ISSN：

2095-9907

年：

2024

卷：

期：

页码：

257

DOI：

10.1038/s41392-024-01962-6

基金类别：

National Natural Science Foundation of China (National Science Foundation of China) [81900232, 32330047, 31930057, 82471593, 81800706]; National Natural Science Foundation of China [LQ19H020011]; Natural Science Foundation of Zhejiang Province [2019M652118]; Chinese Postdoctoral Science Foundation

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Pressure overload-induced cardiac hypertrophy is a common cause of heart failure (HF), and emerging evidence suggests that excessive oxidized lipids have a detrimental effect on cardiomyocytes. However, the key regulator of lipid toxicity in cardiomyocytes during this pathological process remains unknown. Here, we used lipidomics profiling and RNA-seq analysis and found that phosphatidylethanolamines (PEs) and Acsl4 expression are significantly increased in mice with transverse aortic constriction (TAC)-induced HF compared to sham-operated mice...

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Characterization of ferroptosis-triggered pyroptotic signaling in heart failure

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