Advances in crosstalk among innate immune pathways activated by mitochondrial DNA

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tao, Guangwei;Liao, Wenyan;Hou, Jiafeng;Jiang, Xinmiao;Deng, Xin;...

通讯作者：

Chen, Guodong;Ding, CM

作者机构：

[Tao, Guangwei; Ding, CM; Hou, Jiafeng; Ding, Chengming; Chen, Guodong; Chen, GD; Jiang, Xinmiao; Deng, Xin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Tao, Guangwei] Anhui Med Univ, Affiliated Hosp 1, Clin Immunol Inst, Hefei 230032, Anhui, Peoples R China.

[Liao, Wenyan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gynaecol & Obstet, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Ding, CM ; Chen, GD] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Hepatopancreatobiliary Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

mtDNA;TLR9;NLRP3 inflammasome;cGAS-STING signaling pathway

期刊：

Heliyon

ISSN：

2405-8440

年：

2024

卷：

期：

页码：

e24029

DOI：

10.1016/j.heliyon.2024.e24029

基金类别：

Hunan Provincial Natural Science Fund [2021JJ40495, 2022JJ30526, 2022JJ30530]; Clinical Medical Technology Innovation Guidance Project from Department of Science and Technology of Hunan Province [2020SK5181, 2021SK51812]; Scientific Research Fund Project of Hunan Provincial Health Commission [202105010225, 20201950]; Science and Technology Research Project (Basic Applied Research Program) from Department of Science and Technology of Hengyang City [202150063929]

机构署名：

本校为第一且通讯机构

摘要：

Mitochondria are not only the power plant for intracellular oxidative phosphorylation and ATP synthesis, but also involved in cell proliferation, differentiation, signaling and apoptosis. Recent studies have shown that mitochondria play an important role in other pathophysiological functions in addition to cellular energy metabolism. Mitochondria release mitochondrial DNA (mtDNA) as a damage-associated molecular pattern (DAMP) to activate Toll-like receptor 9 (TLR9), NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes...

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Advances in crosstalk among innate immune pathways activated by mitochondrial DNA

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