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Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice

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成果类型:
期刊论文
作者:
Qiuhua Zhou;Yiquan Ou;Xiangsheng Tian;Yujun Ning;Yuwei Mao;...
通讯作者:
Dingxin Long
作者机构:
[Qiuhua Zhou; Xiangsheng Tian; Yujun Ning; Yuwei Mao; Weichao Zhao; Dingxin Long] School of Public Health, Hengyang Medical School, University of South China, Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang 421001, China
Department of nutrition, The First People's Hospital of Chenzhou, Chenzhou 423000, China
[Yiquan Ou] School of Public Health, Hengyang Medical School, University of South China, Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang 421001, China<&wdkj&>Department of nutrition, The First People's Hospital of Chenzhou, Chenzhou 423000, China
通讯机构:
[Dingxin Long] S
School of Public Health, Hengyang Medical School, University of South China, Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, Hengyang 421001, China
语种:
英文
关键词:
Cranial irradiation;Abscopal effects;Ginsenoside Rg1;Testicular apoptosis;HPG axis;SCF/PI3K/AKT/mTOR signaling
期刊:
放射医学与防护(英文)
ISSN:
2666-5557
年:
2025
卷:
6
期:
1
页码:
11-21
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
Objective To investigate whether Ginsenoside Rg1 can mitigate the adverse effects of cranial irradiation on distal reproductive function in mice and to explore the underlying mechanisms. To investigate whether Ginsenoside Rg1 can mitigate the adverse effects of cranial irradiation on distal reproductive function in mice and to explore the underlying mechanisms. Methods Forty male C57BL/6J mice were randomly divided to four groups [Control, irradiation (IR), IR + Rg1, Rg1), IR + Rg1 and Rg1 group treated with intraperitoneal injections of Ginsen...

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