Highly specific characterization and discrimination of monosodium urate crystals in gouty arthritis based on aggregation-induced emission luminogens

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成果类型：

期刊论文

作者：

Wang, Wenjuan;Zhang, Guiquan;Chen, Ziyi;Xu, Hanlin;Zhang, Bohan;...

通讯作者：

Hua, YH;Hu, Rong;Qin, AJ;Hu, R

作者机构：

[Xu, Hanlin; Hua, Yinghui; Wang, Wenjuan; Chen, Ziyi] Fudan Univ, Huashan Hosp, Dept Sports Med, Shanghai 200040, Peoples R China.

[Qin, AJ; Zhang, Guiquan; Qin, Anjun; Hu, Rong; Hu, R] South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.

[Qin, AJ; Zhang, Guiquan; Qin, Anjun; Hu, Rong; Hu, R] South China Univ Technol, AlE Inst, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China.

[Hu, Rong; Hu, R] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Zhang, Bohan] Fudan Univ, Dept Phys, State Key Lab Surface Phys, Shanghai 200433, Peoples R China.

通讯机构：

[Qin, AJ ; Hu, R] S

[Hua, YH ] F

[Hu, R ] U

Fudan Univ, Huashan Hosp, Dept Sports Med, Shanghai 200040, Peoples R China.

South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.

语种：

英文

关键词：

Gout;Monosodium urate;Hydroxyapatite;TPE-Ketoalkyne;Aggregation-induced emission;Confocal laser scanning microscope imaging

期刊：

生物设计与制造(英文)

ISSN：

2096-5524

年：

2023

卷：

期：

页码：

704-717

DOI：

10.1007/s42242-023-00252-4

基金类别：

This work was supported by the Shanghai Science and Technology Committee (No. 22dz1204700), the National Key Ramp;D Program of China (Nos. 2020YFA0803800 and 2017YFE0132200), the National Natural Science Foundation of China (Nos. 82072510, 21907034, 21788 [22dz1204700]; Shanghai Science and Technology Committee [2020YFA0803800, 2017YFE0132200]; National Key Ramp;D Program of China [82072510, 21907034, 21788102, 21525417, 51620105009]; National Natural Science Foundation of China [2019B030301003, 2016A030312002]; Natural Science Foundation of Guangdong Province [ITC-CNERC14S01]; Innovation and Technology Commission of Hong Kong

机构署名：

本校为通讯机构

院系归属：

化学化工学院

摘要：

Existing technologies used to detect monosodium urate (MSU) crystals for gout diagnosis are not ideal due to their low sensitivity and complexity of operation. The purpose of this study was to explore whether aggregation-induced emission luminogens (AIEgens) can be used for highly specific imaging of MSU crystals to assist in the diagnosis of gout. First, we developed a series of luminogens (i.e., tetraphenyl ethylene (TPE)-NH2, TPE-2NH2, TPE-4NH2, TPE-COOH, TPE-2COOH, TPE-4COOH, and TPE-Ketoalkyne), each of which was then evenly mixed with MSU crystals. Next, optimal fluorescence imaging of e...

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Highly specific characterization and discrimination of monosodium urate crystals in gouty arthritis based on aggregation-induced emission luminogens

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