18th International Conference on Intelligent Computing (ICIC)
会议论文集名称：
Lecture Notes in Computer Science
会议时间：
AUG 07-11, 2022
会议地点：
Xian, PEOPLES R CHINA
会议主办单位：
[Luo, Hanyu;Chen, Cheng;Shan, Wenyu;Ding, Pingjian;Luo, Lingyun] Univ South China, Sch Comp Sci, Hengyang 421001, Hunan, Peoples R China.^[Luo, Lingyun] Hunan Med Big Data Int Sci & Technol Innovat Coop, Hengyang 421001, Peoples R China.
主编：
Huang, DS Jo, KH Jing, J Premaratne, P Bevilacqua, V Hussain, A
National Natural Science Foundation of China [62002154]; Hunan Provincial Natural Science Foundation of China [2019JJ50520, 2021JJ40467]; Research Foundation of Hunan Educational Committee [20C1579]; Scientific Research Startup Foundation of University of South China [190XQD096]
机构署名：
本校为第一机构
摘要：
Enhancers are small segments of DNA that bind to proteins (transcription factors) and the transcription of a gene is strengthened after binding to the protein, thus playing an essential role in gene expression. Recently, machine learning-based methods have become a trend in identifying enhancers and their strength. In this study, we propose iEnhancer-BERT, a novel transfer learning method based on pre-trained DNA language model using the whole human genome. More specifically, iEnhancer-BERT consists of a BERT layer for feature extraction and a CNN layer for classification. We initialize our pa...
