Key steps of mycoplasma invasion into host cells: Upon adhesin binding to cell membrane receptors (a), host cells undergo morphological changes characterized by progressive membrane invagination (b). Subsequently, mycoplasma undergo internalization facilitated by protein‐coated vesicles (c) and endosome transport (d). Ultimately, the mycoplasma survives, proliferates within the cell, and localizes to the nucleus (e). Abstract Mycoplasma belong to the genus Mollicutes and are notable for their small genome sizes (500–1300 kb) and limited bios...