Characterization of cholesterol metabolism in Sertoli cells and spermatogenesis (Review)

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shi, Jin-Feng;Li, Yu-Kun;Ren, Kun;Xie, Yuan-Jie;Yin, Wei-Dong*;...

通讯作者：

Yin, Wei-Dong;Mo, Zhong-Cheng

作者机构：

[Ren, Kun; Yin, Wei-Dong; Shi, Jin-Feng] Univ South China, Inst Cardiovasc Dis, Sch Med, 28W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Ren, Kun; Yin, Wei-Dong; Shi, Jin-Feng] Univ South China, Sch Med, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Yin, Wei-Dong; Shi, Jin-Feng] Univ South China, Sch Med, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Xie, Yuan-Jie; Mo, Zhong-Cheng; Li, Yu-Kun] Univ South China, Sch Med, Dept Histol & Embryol, 28W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yin, Wei-Dong; Mo, Zhong-Cheng] U

Univ South China, Inst Cardiovasc Dis, Sch Med, 28W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Med, Dept Histol & Embryol, 28W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

cholesterol;follitropin;insulin;liver X receptor alpha;liver X receptor beta;peroxisome proliferator activated receptor alpha;peroxisome proliferator activated receptor delta;peroxisome proliferator activated receptor gamma;retinoid X receptor alpha;retinoid X receptor beta;retinoid X receptor gamma;scavenger receptor BI;sex hormone;cholesterol;sterol 14alpha demethylase;cholesterol metabolism;cholesterol transport;human;male;metabolic regulation;nonhuman;Review;Sertoli cell;spermatogenesis;gene expression regulation;genetics;lipid metabolism;metabolism;Sertoli cell;spermatogenesis;testis;Cholesterol;Gene Expression Regulation, Developmental;Humans;Lipid Metabolism;Male;Sertoli Cells;Spermatogenesis;Sterol 14-Demethylase;Testis

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2018

卷：

期：

页码：

705-713

DOI：

10.3892/mmr.2017.8000

基金类别：

The present review was supported by grants from the Natural Sciences Foundation of Hunan Province (grant nos. 14JJ2084 and 2015JJ2128), the Zhengxiang Scholar (Xiangyang Tang) Program of the University of South China, The Construct Program of the Key Discipline in Hunan Province (Basic Medicine Sciences in University of South China) and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

The Sertoli cell, which is the supporting cell of spermatogenesis, has an important role in the endocrine and paracrine control of spermatogenesis. Functionally, it provides the cells of the seminiferous epithelium with nutrition, conveys mature spermatids to the lumen of seminiferous tubules, secretes androgen-binding protein and interacts with endocrine Leydig cells. In addition, the levels of cholesterol, as well as its intermediates, vary greatly between nongonadal tissues and the male reproductive system. Throughout spermatogen-esis, a dyn...

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Characterization of cholesterol metabolism in Sertoli cells and spermatogenesis (Review)

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