In-situ monitoring of breast cancer cell (MCF-7) growth and quantification of the cytotoxicity of anticancer drugs fluorouracil and cisplatin

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成果类型：

期刊论文

作者：

Xiao, Xilin;Guo, Manli*;Li, Qiangxiang;Cai, Qingyun;Yao, Shouzhuo;...

通讯作者：

Guo, Manli

作者机构：

[Cai, Qingyun; Xiao, Xilin; Guo, Manli; Yao, Shouzhuo] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemobiosensing & Chemomet, Changsha 410082, Hunan, Peoples R China.

[Xiao, Xilin] Univ S China, Coll Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Li, Qiangxiang] Cent S Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

[Grimes, Craig A.] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.

[Grimes, Craig A.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.

通讯机构：

[Guo, Manli] H

Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemobiosensing & Chemomet, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

Cytotoxicity;Human breast cancer cells (MCF-7);Magnetoelastic sensor;Wireless

期刊：

Biosensors and Bioelectronics

ISSN：

0956-5663

年：

2008

卷：

期：

页码：

247-252

DOI：

10.1016/j.bios.2008.03.041

基金类别：

We are grateful for the financial support from the National Natural Science Foundation of China under the grant 20475016, 20775024 and 20335020, and the Specialized Research Fund for the Doctoral Program of Higher Education under grant 20050532024.

机构署名：

本校为其他机构

院系归属：

化学化工学院

摘要：

A wireless sensing device was developed for the in-situ monitoring of the growth of human breast cancer cells (MCF-7) and evaluation of the cytotoxicity of the anticancer drugs fluorouracil and cisplatin. The sensor is fabricated by coating a magnetoelastic ribbon-like sensor with a layer of polyurethane that protects the iron-rich sensor from oxidation and provides a cell-compatible surface. In response to a time-varying magnetic field, the magnetoelastic sensor longitudinally vibrates, emitting magnetic flux that can be remotely detected by a...

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In-situ monitoring of breast cancer cell (MCF-7) growth and quantification of the cytotoxicity of anticancer drugs fluorouracil and cisplatin

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