RETRACTED: Betulinic acid downregulates expression of oxidative stress-induced lipoprotein lipase via the PKC/ERK/c-Fos pathway in RAW264.7 macrophages

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成果类型：

期刊论文

作者：

Peng, Juan;Lv, Yun-Cheng;He, Ping-Ping;Tang, Yan-Yan;Xie, Wei;...

通讯作者：

Yin, Wei-Dong

作者机构：

[Lan, Gan; He, Ping-Ping; Shi, Jin-Feng; Peng, Juan; Zhang, Min; Li, Yuan; Lv, Yun-Cheng; Tang, Chao-Ke; Yin, Wei-Dong; Xie, Wei; Tang, Yan-Yan; Zhang, Chi] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Peng, Juan] Yongzhou Vocat & Tech Coll, Yongzhou 425000, Hunan, Peoples R China.

[He, Ping-Ping] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Liu, Xiang-Yu] Univ South, Sch Life Sci & Technol, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Yin, Wei-Dong] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Betulinic acid;LPL;Oxidative stress

期刊：

Biochimie

ISSN：

0300-9084

年：

2015

卷：

119

页码：

192-203

DOI：

10.1016/j.biochi.2015.10.020

基金类别：

The authors gratefully acknowledge the ﬁnancial support from the National Natural Sciences Foundation of China ( 81270269 , 81070220 , 81170278 , 81300158 and 81100106 ), and Hunan Provincial Natural Science Foundation of China ( 14JJ2084 ). Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions ( 2008-244 ) of Hunan Province, and the construct program of the key discipline in Hunan Province, China .

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

护理学院

摘要：

Background Atherosclerosis is a major cause of coronary artery disease, which is characterized by cellular lipid accumulation. Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism. Studies have shown that macrophage-derived LPL exhibits proatherogenic properties, and plays a major role in lipid accumulation in macrophages. Evidence suggests that oxidative stress can effectively enhance macrophage LPL production. Betulinic acid (BA) is a pentacyclic lupane triterpene with a potent antioxidant activity. In this study, we investigated whet...

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RETRACTED: Betulinic acid downregulates expression of oxidative stress-induced lipoprotein lipase via the PKC/ERK/c-Fos pathway in RAW264.7 macrophages

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