Inhibition of Hydrogen Sulfide Generation Contributes to 1-Methy-4-Phenylpyridinium Ion-Induced Neurotoxicity

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Xiao-Qing*;Fan, Li-Li;Li, Yu-Juan;Shen, Xin-Tian;Zhuan, Yuan-Yuan;...

通讯作者：

Tang, Xiao-Qing

作者机构：

[Li, Yu-Juan; Tang, Xiao-Qing; Fan, Li-Li; Hu, Bi; He, Jian-Qin; Shen, Xin-Tian; Zhuan, Yuan-Yuan] Univ S China, Dept Physiol, Coll Med, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing; Li, Yuan-Jian] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Shen, Xin-Tian] Huaihua Med Coll, Dept Physiol, Huaihua 418000, Hunan, Peoples R China.

[Xu, Jin-Hua] Univ S China, Lab Ctr Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ S China, Dept Physiol, Coll Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing] U

Univ S China, Dept Physiol, Coll Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Hydrogen sulfide;1-Methy-4-phenylpyridinium ion;Cystathionine-beta-synthetase;PC12 cells;Neurotoxicity

期刊：

Neurotoxicity Research

ISSN：

1029-8428

年：

2011

卷：

期：

页码：

403-411

DOI：

10.1007/s12640-010-9180-4

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30770740]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [06JJ2074]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2005038233]; Plan Project for Scientific Research, Department of Science and Technology, Hunan ProvinceDepartment of Science & Technology (India) [05FJ3039]; Research Foundation of Education Bureau of Hunan Province [06C700]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP +). Increasing studies have shown that hydrogen sulfide (H 2S) is an endogenous antioxidant gas. We have hypothesized that MPP +-caused neurotoxicity may involve the imbalance of proportion to this endogenous protective antioxidant gas. The aim of this study is to evaluate whether MPP + disturbs H 2S synthesis in PC12 cells, a clonal rat pheochromocytoma cell line, and whether disturbance of H 2S generation induced by MPP + is an...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Inhibition of Hydrogen Sulfide Generation Contributes to 1-Methy-4-Phenylpyridinium Ion-Induced Neurotoxicity

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问