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13-lncRNAs Signature to Improve Diagnostic and Prognostic Prediction of Hepatocellular Carcinoma

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成果类型:
期刊论文
作者:
Zhang, Xinxin;Yu, Jia;Hu, Juan;Tan, Fang;Zhou, Juan;...
通讯作者:
Lei, X.
作者机构:
[Hu, Juan; Yang, Xiaoyan; Xie, Zhizhong; Tan, Fang; Zhou, Juan; Lei, Xiaoyong; Dong, Sen; Zhang, Xinxin; Yu, Jia] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang, Peoples R China.
[Tang, Huifang] Univ South China, Affiliated Hosp 1, Hengyang, Peoples R China.
通讯机构:
[Lei, X.] I
Institute of Pharmacy and Pharmacology, No. 28, West Changsheng Road, China
语种:
英文
关键词:
Bioinformatics analysis;Diagnosis;HCC;LncRNAs;Prognosis;TCGA
期刊:
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
ISSN:
1386-2073
年:
2021
卷:
24
期:
5
页码:
656-667
基金类别:
The Natural Science Foundation of Hunan Province (No. 2017JJ2226, 2018JJ3454 and 2019JJ50500). The Science and Technology Development Project of Hengyang (No. 2017KJ286). The funding of the National Students' Training Program for Innovation and Entrepreneurship (No. 8523). Hunan Provincial Students' Training Program for Innovation and Entrepreneurship (No.2315).
机构署名:
本校为第一机构
院系归属:
药学与生物科学学院
摘要:
Background: Hepatocellular carcinoma (HCC) is a common type of cancer with a high mortality rate and is usually detected at the middle or late stage, missing the optimal treatment period. The current study aims to identify potential long non-coding RNA (lncRNAs) biomarkers that contribute to the diagnosis and prognosis of HCC. Methods: The differentially expressed lncRNAs (DElncRNAs) in HCC patientsThe differentially expressed lncRNAs (DElncRNAs) in HCC patients were detected from the Cancer Genome Atlas (TCGA) dataset. LncRNAs signature was screened by LASSO regression, univariate, and mul...

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