Anti-proliferative activity and structure-activity relationship of honokiol derivatives.

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成果类型：

期刊论文

作者：

Lin, Ding;Yan, Zhongzhong;Chen, Aiyu;Ye, Jiao;Hu, Aixi*;...

通讯作者：

Hu, Aixi

作者机构：

[Lin, Ding; Ye, Jiao; Chen, Aiyu; Yan, Zhongzhong; Hu, Aixi] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China.

[Lin, Ding] Zhejiang A&F Univ, Dept Tradit Chinese Med, Hangzhou 311300, Zhejiang, Peoples R China.

[Liu, Juan; Peng, Junmei] Univ South China, Coll Pharm & Biol Sci, Hengyang 421000, Peoples R China.

[Wu, Xiaoyun] Southern Med Univ, Guangdong Prov Key Lab New Drug Screening, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China.

通讯机构：

[Hu, Aixi] H

Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

3D-QASR;Anti-proliferative;Honokiol;Structure-activity relationship;Theoretical calculations

期刊：

Bioorganic & Medicinal Chemistry

ISSN：

0968-0896

年：

2019

卷：

期：

页码：

3729-3734

DOI：

10.1016/j.bmc.2019.06.042

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21442014]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

As a known natural product with anti-tumor activity, honokiol has been widely researched and structural modified. Lots of honokiol derivatives have been found to possess good anti-proliferative activity and showed great potential in cancer therapy, but the SAR (structure-activity relationship) was still confused. Here in, the SAR were comprehensively researched by summary of reported derivatives and synthesis of novel derivatives. Amongst novel derivatives, the promising compounds A6 and A10 exhibited potent and selective anti-proliferative act...

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Anti-proliferative activity and structure-activity relationship of honokiol derivatives.

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