期刊论文

Research advances of m^6A methylation and metabolic disease

中文

中国动脉硬化杂志

1007-3949

2020

28

11

1002-1008

10.3969/j.issn.1007-3949.2020.11.015

81970390:国家自然科学基金 81470569:国家自然科学基金 2018JJ2341:湖南省自然科学基金 201710555015:国家级大学生创新创业训练计划项目 201710555010:国家级大学生创新创业训练计划项目

本校为第一机构

N6-甲基腺嘌呤(N6-methyladenosine,m^6 A)是腺嘌呤(A)第6位氮原子被甲基转移酶催化形成的一种RNA甲基化修饰,是真核生物信使RNA(mRNA)上最多的化学修饰形式。近年来研究发现m^6 A对RNA在脂肪组织生成、细胞分化和免疫/炎症反应等过程中发挥重要的调控作用。代谢性疾病是由体内蛋白质、葡萄糖和脂质代谢紊乱引起的一类慢性炎症疾病。在肥胖、2型糖尿病和心血管疾病等代谢性疾病的发生发展中,m^6 A甲基化修饰通过调控糖脂代谢和免疫/炎症发挥着重要角色。文章拟对m^6 A甲基化在代谢性疾病中的作用做一综述,并从表观转录组学的角度为代谢性疾病的防治提供新的思路。

m^6 A methyladenosine is a methylation modification catalyzed by methyltransferase at the 6th position nitrogen atom of adenine(A),which is the most common chemical modification on eukaryotic messenger RNA(mRNA).Recently,m^6 A has been found to play an important role in the dynamic regulation of RNA,which is crucial for the basic physiological processes such as adipogenesis,cell differentiation and immune/inflammatory response.Metabolic diseases are series of disorders caused by metabolic dysfunction of proteins,glucose and lipid in the body.The studies have shown that m^6 A methylation plays ...