期刊论文

中文

中国动脉硬化杂志

1007-3949

2019

27

1

81-86

10.3969/j.issn.1007-3949.2019.01.016

国家自然科学基金项目(81570408).

本校为第一机构

甘油三酯(TG)主要存在于富含甘油三酯脂蛋白(TRLs)中,TRLs代谢失调与动脉粥样硬化发生发展密切相关。脂蛋白脂酶(LPL)是一种由实质细胞分泌的糖蛋白,可将TRLs中的TG分解为游离脂肪酸。许多因子通过调控LPL表达与活性影响TRLs代谢及动脉粥样硬化进程。因此,阐明TRLs代谢及调控机制对于心血管疾病防治具有重要意义。

Triglyceride(TG) is predominantly present in triglyceride-rich lipoproteins(TRLs).Dysregulation of TRL metabolism is closely associated with the occurrence and development of atherosclerosis.Lipoprotein lipase(LPL),a glycoprotein secreted by parenchyma cells,can cleave TG within the TRLs to produce free fatty acid.A variety of factors are involved in TRL metabolism and atherosclerosis progression by regulating LPL expression and activity.Thus,clarifying the role TRL metabolism and its regulatory mechanisms could have significant im...