期刊论文

The mechanism of drugs and small molecules on lipid metabolism regulation via reverse cholesterol transport key proteins

中文

中国动脉硬化杂志

1007-3949

2018

26

4

325-328

10.3969/j.issn.1007-3949.2018.04.001

国家自然科学基金（81770461）；

本校为第一机构

胆固醇逆向转运（RCT）异常导致脂代谢紊乱是动脉粥样硬化发病重要环节,探讨介导RCT的关键蛋白在脂代谢中的作用及调控机制对阐明动脉粥样硬化发病的分子机制具有重要意义。本期专题收集的论文探讨了利拉鲁肽、苦瓜素以及生长分化因子11对细胞胆固醇流出及介导RCT中关键蛋白三磷酸腺苷结合盒转运体A1（ABCA1）、ABCG1和B类Ⅰ型清道夫受体表达的影响,分别从不同角度阐释RCT关键蛋白参与药物或小分子物质调控胆固醇流出的分子机制。

The abnormality of reverse cholesterol transport（ RCT） induces the disorder of lipid metabolism,which is a key factor in the pathogenesis of atherosclerosis. It is important to explore the roles and regulatory mechanisms of key proteins mediated RCT in lipid metabolism. These are also important significance to elucidate the molecular mechanism of atherosclerosis. In this topic collection papers,we discuss the effects of liraglutide,momordicin and growth differentiation factor 11 on cholesterol efflux and the expressions of key proteins ATP-bi...