期刊论文

中文

中国动脉硬化杂志

1007-3949

2018

26

7

655-657

10.3969/j.issn.1007-3949.2018.07.002

国家自然科学基金项目（81770461）；

本校为第一机构

胆固醇逆向转运（RCT）是促进细胞内胆固醇流出并转运至肝脏进行代谢的过程,其功能异常在动脉粥样硬化（As）的发生发展中起着关键作用。糖尿病、肥胖等慢性代谢性炎症疾病促进As的进展,而体内炎症、脂肪因子参与调控RCT是其重要的调控机制之一。本期专题收集的研究论文和综述探讨了糖基化终末产物Nε-羧甲基赖氨酸、核因子κB（NF-κB）、脂肪因子Visfatin等对细胞内胆固醇流出及介导RCT中关键蛋白三磷酸腺苷结合盒转运体A1、Sortilin、酯酰辅酶A：胆固醇酰基转移酶（ACAT）等表达的影响,从不同角度阐释慢性代谢性炎症疾病调控RCT和心血管疾病发生发展的分子机制。

Reverse cholesterol transport（ RCT） is a process that promotes the efflux of cholesterol from the cells and transports it to the liver for metabolism. Its dysfunction plays a key role in the development of atherosclerosis（ As）.Chronic metabolic inflammatory diseases including diabetes,obesity promote the progress of As,in which pro-inflammatory cytokines and adipokines are important regulatory mechanisms for the regulation of RCT in vivo. The research papers and review collected in this issue studied the effect of nuclear factor κB（ NF-κ...