Peroxiredoxins are highly conserved peroxidases. Although the thioredoxin peroxidase activity of peroxiredoxin（Prx） is important to maintain low levels of endogenous hydrogen peroxide,Prx has also been shown to promote hydrogen peroxide-mediated signalling. Mitogen activated protein kinase（MAPK） signalling pathways mediate cellular responses to a variety of stimuli,including reactive oxygen species（ROS）. Here we review the evidence that Prx can act as both sensors and barriers to the activation of MAPK and discuss the underlying mechanisms invol...
