期刊论文

The Relationship Between Plasma Retinol-binding Protein 4 and Subclinical Atherosclerosis in Newly Diagnosed Type 2 Diabetic Patients

中文

轧钢

1003-9996

2016

24

4

381-385

2013FJ4236:湖南省自然科学基金 20110162120014:高等学校博士学科点专项科研基金 13B098:湖南省教育厅优秀青年项目

本校为第一机构

目的 探讨新诊2型糖尿病(T2DM)患者血浆视黄醇结合蛋白4(RBP4)与亚临床动脉粥样硬化(subAs)的关系.方法 对217例新诊T2DM患者测定血浆RBP4浓度、空腹及餐后血糖、糖化血红蛋白、血脂、空腹胰岛素及颈总动脉内膜中膜厚度(IMT)、髂总动脉IMT、股动脉IMT,分析其subAs的发生情况.结果 合并subAs的T2DM患者平均年龄、空腹胰岛素、血浆RBP4浓度均高于非subAs组患者(均P＜0.05).将患者按RBP4浓度三分位数分组,随RBP4浓度增加,患者颈总动脉IMT、髂总动脉IMT、股动脉IMT均增加,高浓度RBP4组患者的颈总动脉IMT高于其余两组(P＜0.05);随RBP4浓度增加,subAs患病率也逐步升高,高浓度RBP4组患者的subAs患病率显...

Aim To evaluate the relationship between the concentration of plasma retinol-binding protein 4（ RBP4） and subclinical atherosclerosis（ subAs） in newly diagnosed type 2 diabetes mellitus（ T2DM） patients.Methods 217 newly diagnosed T2DM patients were selected.Plasma RBP4 concentration,fasting and postprandial blood glucose,glycosylated hemoglobin A1（ Hb A1c）,blood lipid,fasting insulin（ FINS） and common carotid artery intima-media thickness（ IMT）,common iliac artery IMT,femoral artery IMT were measured.The occurrence of subAs in patie...