Aim To investigate the effects of hydrogen sulfide(H2S) on ox-LDL uptake of THP-1-derived macrophages and its underlying mechanisms. Methods Fluorescence microscopy,RT-PCR and western blot were performed. Results Incubation of macrophages with DiI-ox-LDL led to ox-LDL uptake of macrophages.Sodium hydrosulfide(NaHS,an H2S donor) decreased ox-LDL uptake. While DL-propargylglgycine(PPG) exerted opposite effects.Furthermore,ox-LDL markedly induced CD36 mRNA and protein expression in macrophages,which was abolished by NaHS(50 to 100 μmol/L)...