Aim To observe the binding specificity of aptamers and THP-1 macrophage derived foam cells and atheroselerotic lesions. Methods The FITC-labeled PM1, binding to THP-1 macrophages, vascular smooth cells, endothelial cells and THP-1 macrophage derived foam cells were observed by fluorescence microscopy respectivly. Model of atherosclerosis was formed by high-fat feeding rabbit methods. The binding of aptamers and atherosclerotic lesions were detected by fluorescence microscopy and PCR. Results PM1 didn＇ t bind to THP-I macrophages, vascular smoo...
