Aim To observe the expression of cathepsin L（Cat L） in atherosclerotic lesion and investigate its role in lipid accumulation of macrophage. Methods Atherosclerosis model of rabbit carotid artery was established by using ringer of carotid artery.Immunohistochemisty was taken to examine the expression of Cat L in plaques.RAW264.7 macrophage was cultured and treated with various concentrations of oxidized low density lipoprotein（ox-LDL）.The mRNA level,the protein expression and the activity of Cat L were detected by reverse transcription polym...
