期刊论文

中文

中国动脉硬化杂志

1007-3949

2010

18

7

552-555

湖南省卫生厅课题（C2008-011） 湖南省科技计划项目（2009FJ3033） 诺美国际基金资助项目

本校为第一机构

目的 研究普罗布考对2型糖尿病非增殖型糖尿病视网膜病变患者血脂、抗氧化能力、视功能及眼底形态的影响,为普罗布考防治早期糖尿病视网膜病变提供临床依据.方法 纳入66例伴非增殖型糖尿病视网膜病变的2型糖尿病患者127眼,随机分为对照组和治疗组,对照组进行强化降血糖和降血压治疗,治疗组在强化治疗基础上口服普罗布考0.375 g,每天2次,总疗程为12个月.治疗前后两组患者均进行了血脂、血清总抗氧化能力、视力、眼底及眼底荧光血管造影检查.结果 共有62例120眼完成研究,普罗布考显著降低了患者总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平,显著提高患者总抗氧化能力和视力(P

Aim To study the influence of probucol on the type 2 diabetic mellitus patients with non-proliferative diabetic retinopathy（NPDR） about blood lipids,antioxidant capacity,visual function and retinal morphology,so as to provide clinical basis for the prevention and treatment of early DR by probucol. Methods 66 type 2 diabetes patients with 127 NPDR eyes were included.Patients were randomly divided into control and treatment groups： the control group were treated by intensive therapy of blood glucose and blood pressure control,the treatment gro...