Aim To investigate the effects of probucol on high fat-high cholesterol （HFHC） diet-induced hyperlipidemia and oxidative stress in apo E deficient（ apoE^-/- ） mice and genetic background C57BL/6J mice. Methods The hyperlipidemic mice were induced by feeding HFHC diet which was supplemented with 15%lard and 0.25% cholesterol. The levels of plasma lipids were determined by standard assays. The oxidative stress was evaluated by the serum levels of total antioxidant capacity （T-AOC）, superoxide dismutasc （SOD）, and malonic dialdehyde （MI）...
