期刊论文

中文

中国动脉硬化杂志

1007-3949

2004

12

4

387-391

10.3969/j.issn.1007-3949.2004.04.004

日本大制药厂新药研究基金 （ 2 0 0 1 8 2 8）； 湖南省教育厅课题 （JY 0 1C193 ）资助；

本校为第一机构

为了探讨脂蛋白脂肪酶活化剂NO-1886对高脂高糖饮食喂养贵州小香猪过氧化物体增殖物激活型受体、脂蛋白脂肪酶及肿瘤坏死因子α表达的影响,选择雄性贵州小香猪15头,随机分为3组.正常对照组喂普通饲料;高脂高糖组喂高脂高蔗糖饲料;治疗组喂高脂高蔗糖饲料4个月后加1%NO-1886治疗.8个月后处死动物,采用Trizol提取组织总RNA,逆转录聚合酶链反应检测过氧化体增殖物激活型受体、脂蛋白脂肪酶及肿瘤坏死因子α mRNA的表达.结果发现,正常对照组肌肉组织和肝脏过氧化体增殖物激活型受体α的表达较低.高脂高糖组肌肉组织和肝脏过氧化体增殖物激活型受体α的表达增强,NO-1886使高脂高糖喂养增强肌肉组织和...

Aim To investigate the role of lipoprotein lipase ( LPL) activator NO-1886 on the mRNA expression of peroxisome proliferator-activated receptors (PPAR), LPL and tumor necrosis factor-α (TNF-α) in Guizhou minipigs fed with high-fat and high-sucrose. Methods Guizhou minipigs were randomized in to three groups: control group, high-fat high-sucrose group, high-fat high-sucrose and NO-1886 treated group (1% NO-1886 supplemented into the diet after 4 months). Reverse transcription-polymerase chain reaction (RT-PCR) analysis of PPAR, LPL and TNF-α ...