期刊论文

中文

中国动脉硬化杂志

1007-3949

2002

10

4

307-311

10.3969/j.issn.1007-3949.2002.04.010

ProjectsupportedbytheTsinghuaUnisplendourGuhanBio pharmaceuticalCorporationLtd .ofChina；

本校为其他机构

目的研究人血高密度脂蛋白(HDL)注射液对喂高胆固醇饲料家兔主动脉粥样指纹病变的影响.方法实验家兔给与1%胆固醇饲料8周.在此期间,HDL组每只家兔每周静脉注射50 mg人血HDL;洛伐他汀组每只家兔每天皮下注射10mg洛伐他汀;安慰剂组每只家兔每天静脉注射20mL生理盐水.人血HDL注射液由清华紫光古汉生物制药集团有限公司生产并提供.结果在试验期间,各组实验动物喂高胆固醇饲料后血脂水平均有升高.第八周后,实验动物主动脉内膜表面富脂粥样病变面积比分别为:安慰剂组32.6%±21.7%(x±s,下同);HDL组9.16%±7.87%;洛伐他汀组20.8%±13.1%.血清总胆固醇水平分别为:安慰剂组10.0±2.30g/L;HDL组2.92±1.41...

Aim The effects of in vivo administration of human high density lipoprotein (HDL) injection on the development of aortic streaks were studied in cholesterol-fed rabbits. Methods The rabbits received a 1% cholesterol-rich diet for 8 weeks. During this period, the HDL group was intravenously administered with 50 mg/week of HDL injection; the lovastatin group was administered with 10 mg/day of lovastatin via subcutaneous injection; the placebo group received normal saline (0.9% NaCl). The HDL injection was manufactured and provided by Tsinghua Uni...