ABSTRACTAim To investigate the effects and mechanism oframiprilat on c-myc expression induced by oxidized lowdensity lipoprotein (x-LDL) in vascular endothelialcells.Method After endothelial cells incubated with ox-LDL (250 mg/L) , ox-LDL+ramiprilat (20 mol/L) ,ox-LDL+ ramiprilat (40 mol/L) + N-Arg (1 00 mol/L ) , ox-LDL+N-Arg for 4 h in vitro. Reverse tran-scription PCR technique was employed to measure c-myc mRNA of cultured human umbilical vein endothe-lial cells (HUVEC). Nitric oxide (NO) and cGMPwere assayed by means of Griess reaction and radioim-munoassy respectively.Results in response...