期刊论文

Level of Plasma L-arginine, Serum NO_2~-, NO_3~- and Tissue Plasminogen Activator in Patients with Coronary Heart Disease and Hyperlipemia

中文

中国动脉硬化杂志

1007-3949

1997

005

4

331-333

本校为第一机构

观察30例冠心病高脂血症患者和16例正常人脂过氧化物、L-精氨酸、硝酸根、亚硝酸根、组织型纤溶酶原激活物和纤溶酶原激活物抑制剂水平的变化。结果发现，冠心病高脂血症患者L-精氨酸水平、组织型纤溶酶原激活物和超氧化物歧化酶活性下降（与对照组相比，P＜0．05），硝酸根、亚硝酸根及脂过氧化物水平升高（P＜0．05）。结果提示冠心病高脂血症患者血浆中L-精氨酸相对缺乏，可能与其一氧化氮需要量增加有关；血清中硝酸根和亚硝酸根的含量增加，可能与一氧化氮的降解增加有关；组织型纤溶酶原激活物活性降低可能与细胞功能障碍有关。

Aim To investigate the change of plasma L-arginine, serum NO2 , NO3 and tissue plasminogen activator (t-PA) in patients with coronary heart disease and haperlipemia.Methods The method of Pico-Taq TM amino acid analysis was introduced to measure the level of L-arginine. Serum NO2 and NO3 was observed by catalytic photometric method. Serum t-PA was measured by enzyme linked immunosorbent assay.Results The levels of plasma L-arginine (patients vs control group: 89±8μmol/L vs 113±5 μmol/L),serum superoxide dismutase (patients vs control group: ...