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The size-dependent apoptotic effect of titanium dioxide nanoparticles on endothelial cells by the intracellular pathway

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成果类型:
期刊论文
作者:
Zeng, Can;Feng, Yuqin;Wang, Wuxiang;Zhou, Furong;Liao, Fen;...
通讯作者:
Feng, Shaolong
作者机构:
[Feng, Shaolong; Wang, Wuxiang; Liu, Yuanfeng; Zeng, Can; Zhou, Furong; Liao, Fen] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
[Feng, Yuqin] Jilin Univ, Coll Mat Sci & Engn, Changchun, Jilin, Peoples R China.
[Wang, Wuxiang] Univ South China, The Lib, Hengyang, Peoples R China.
通讯机构:
[Feng, Shaolong] U
Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
apoptosis;endothelial cell (EC);p53;titanium dioxide nanoparticle (nano-TiO2)
期刊:
ENVIRONMENTAL TOXICOLOGY
ISSN:
1520-4081
年:
2018
卷:
33
期:
12
页码:
1221-1228
基金类别:
Foundation of University of South China, China, Grant/Award Number: 2012XQD44; Science and Technology Foundation from Guangdong Province, Grant/Award Number: 2014B030301060
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
AbstractConcerns over the health risk of the widely distributed, commonly used titanium dioxide nanoparticles (nano‐TiO2) are increasing worldwide. Yet, up‐to‐now, our understanding in their potential effects on the cardiovascular system is very limited and the toxicological mechanisms are still unclear. In the present study, the CCK‐8 assay was performed to determine the cytotoxicity of four sizes (10, 30, 50, and 100 nm) of anatase nano‐TiO2 on human umbilical vein endothelial cells (HUVECs) in culture, and the flow cytometry was employ...

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