National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30772116, 30801335]; Construct Program of the Key Discipline in Hunan Province; Opening Foundation of Key Lab of Hunan Province [09K075]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Aims and background. The mechanisms of Epstein-Barr virus (EBV)-associated tumor development are incompletely understood. The aim of this study was to investigate the gene expression of EBV-associated lymphomas in hu-PBL/SCID mice. Methods. Human peripheral blood lymphocytes (hu-PBL) from EBV-seropositive donors were transplanted into severe combined immunodeficiency (SCID) mice. In situ hybridization was used to detect EBV-encoded small RNA-1 (EBER1) in tumor tissues. Mutation of TP53 exons 5-8 in EBV-induced lymphomas was analyzed by PCR-SSCP. Immunohistochemical staining was used to examine...
